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25.05.2023
Life science, Spheroid culture, spheroids

Necrosis and its formation in a spheroid

The term necrosis refers to cell or tissue death and is typically caused by factors such as injury, infection, or inadequate blood supply. Necrosis can also form within a spheroid, which is a 3D culture of cells. Here are a few

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By admin.facellitate
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BIOFLOAT FLEX SOLUTION
19.05.2023
Cell culture, cells, Life science, spheroids, Stem Cells

Factors affecting tumor spheroid formation for cancer research

Tumor spheroids are three-dimensional cell culture models that have gained significant attention in cancer research because they provide a more physiologically relevant environment for studying tumor biology compared to traditional two-dimensional cell culture systems. 3D spheroids contain a dense network of

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By admin.facellitate
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19.05.2023
Life science, spheroids

Spheroid formation: Mechanism and role of the substrate

Spheroids grow in three dimensions to form a sphere-like structure which mimics cell in vivo microenvironment more closely than conventional 2D monolayer cell culture. They can be formed from single or multiple cell types that are commonly used in research

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By admin.facellitate
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24.02.2023
3d cell culture, Life science, spheroids

Using Biopolymers And Micromachining Technology In Generating Multicellular Spheroids

Multicellular spheroids (MCSs) are formed through spontaneous aggregation of cells in the presence of adhesion molecules known as cadherins (1). Decades of research have proved MCSs to be an efficient 3D cell culture model for a wide array of research.

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By admin.facellitate
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03.02.2023
Life science, Spheroid culture, spheroids

How to Generate Multicellular Spheroids

Since the introduction of monolayer cell cultures, cell culture methods have advanced exponentially in the past decade, moving from traditional 2D cell culture methods to 3D cultures. While 2D cultures are simple and allows for cell proliferation and differentiation, they

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By admin.facellitate
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13.09.2022
Life science, spheroids

Spheroids and three-dimensional stem cell cultures

A spheroid culture system provides a similar physiochemical environment to in vivo, by facilitating cell-cell and cell-matrix interaction to overcome the limitations of traditional monolayer cell cultures. Due to the importance of stem cell culture systems in clinical applications, researchers

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By admin.facellitate
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18.08.2022
Life science, spheroids

Homotypic and heterotypic spheroids

Solid tumors are composed of a number of different types of cells. These include cancer cells, stromal cells such as fibroblasts, immune cells, lymphatic endothelial cells, vascular endothelial cells, pericytes and adipocytes (1). These cells by it self are not

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By admin.facellitate
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3d bioprinting
09.08.2022
Life science, spheroids

Spheroids And Their Application In 3D Bioprinting

Spheroids are recognized as physiologically relevant three-dimensional models that could capture the major characteristics of both healthy and diseased tissues. Considering its high cell density, increased deposition of extracellular matrix and accelerated proliferation rates, spheroid-based tumour models can greatly reduce

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By admin.facellitate
0
02.08.2022
Life science, spheroids

Forming Compact Spheroids

Spheroids, which are self, assembled cellular aggregates, as a representative 3D model of solid tumors is largely dependent on the uniformity of its size and shape. Uniform spheroids yield reproducible results in drug screens as well as obtaining meaningful findings

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By admin.facellitate
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02.08.2022
Life science, News, spheroids

Spheroid Models To Study Lung Cancer

Spheroid model has been shown to have features consistent with patient specific Non-Small Cell Lung Cancer Spheroid tumours (NSCLC), characterised by extremely high clonal and morphological heterogeneity of tumours and multi-drug resistance. Lung malignancies accounts for 11% of cancer worldwide

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