Organoids can be defined as three-dimensional multicellular in vitro tissue culture that has the capability to mimic its corresponding in vivo organ, so that they can be put in use to study characteristics of that…
Among the neurodegenerative diseases, MS is the most common chronic disease prevalent among the young adult population with an early onset at 20-40 years of age, with a high occurrence among women (1). MS is…
Neurodegenerative diseases are primarily characterized by the formation and aggregation of misfolded protein in the central nervous system. Prion diseases; a group of rare and fatal brain disease is caused by misfolding of cellular prion…
The limitations of 2D cultures have paved the way for the development of 3D cell culture models of Alzheimer’s disease (AD). AD is a neurodegenerative disorder comprised of progressive decline of cognitive abilities and behaviour…
Wondering what these tiny clumps of cells are? let’s have a look. WHAT ARE SPHEROIDS? Spheroids are three-dimensional (3D) cell aggregate to better stimulate a in-vivo like environment as compared to a two-dimensional model. Compared…
Cells grown in 3D systems develop into physiologically relevant structures comprising of in-vivo like cellular microenvironment that determine gene expression, growth behavior and specific biochemical functions of organs (1). 3D spheroids of fish and fish…
In the recent years most drugs designed to treat neurodegenerative disorders, have failed to produce desired effects at the clinical trial phase. This points towards a strong inability in conventional 2D culture assays, and animal…
Over the past several years, various types of 3D cultures systems have acquired attention and increased recognition as an important tool for research. This trend has also been illustrated, In Alison Abbotts 2003 nature report…