Key differences between cancer cells and normal cells
Normally, human cells grow and divide to form new cells and as the cells grow old or are damaged, they are replace with new cells. When this order of cell cycle breaks down and cells proliferate abnormally, they form tumors that can be cancerous or non-cancerous. Cancer is still a significant concern for public health as it can start anywhere in the human body, where it grows and spreads uncontrollably. Cancer cells are invasive and can invade nearby tissues or travel to distant places in the body to form new tumors, also called metastasis (1).
This article covers key points in which normal cells differ from cancerous cells (2,3).
|Appearance under the microscope|
|Immune system invasion|
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- Zhu S, Wang J, Zellmer L, Xu N, Liu M, Hu Y, Ma H, Deng F, Yang W, Liao DJ. Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research. J Cancer. 2022 Jul 4;13(9):2810-2843. doi: 10.7150/jca.72628. PMID: 35912015; PMCID: PMC9330459.
- Chen P, Hsu WH, Han J, Xia Y, DePinho RA. Cancer Stemness Meets Immunity: From Mechanism to Therapy. Cell Rep. 2021 Jan 5;34(1):108597. doi: 10.1016/j.celrep.2020.108597. PMID: 33406434; PMCID: PMC7839836.