Category Organoids

Organoids constitute an improved model system in which cell types more closely resemble the in vivo situation and are in similar conditions to those found in the human body. Diverse organoid systems provide a useful…

Organoid research has been an emerging filed in the past few decades since organoids have the potential to provide better cancer drug screening. While cell culture is important for determining whether a drug should advance…

Organoids are self-organized 3D structures derived from adult or embryonic stem cells that are able to represent the structure and function of the derived tissue. They are able to accurately mimic tissue specific structure and…

Organoid technology is improving rapidly with effective incorporation of immune cells and vascularization, which often represents the major hurdles in this technology. Other advancements are to facilitate new discovery research and drug development efforts. Glioblastoma…

Bian et al. recently developed protocols for genetically manipulating cerebral organoids to induce glioblastoma tumor growth named neoplastic cerebral organoids. This method uses CRISPR-based genome editing tools to create either oncogenic mutation or induce the…

To address the modelling of cell-to-cell communication with the cell population and the development of vasculature in organoid system, significant progress has been achieved with blood vessels organoids which shows a great potential to impact…

A human model system is preferable to animal models when studying infectious diseases pathogenesis because pathogens often have a narrow species or tissue tropism, meaning that they infect only certain species and sometimes certain cell…

Human organoid system fundamentally mimic a part of the human body but not the entire body. Organoid system lacks the interorgan communication. Therefore, human organoids are limited to reproduction of organ-specific or tissue-specific micro physiology,…

A brain organoid is a self-organizing three-dimensional tissue structure derived from human embryonic stem cells or pluripotent stem cells. They show the ability to stimulate the architecture and functionality of the human brain. Recent publications…

Human organoids are a vital source for precision medicine. They can be useful to select an appropriate drug for the patients with genetic diseases or cancer. Cystic fibrosis is a relatively common genetic disease with…