faCellitate announced the launch of the BIOFLOAT™ 1536-well ultra-low-attachment (ULA) plate, engineered to deliver rapid, uniform spheroids and reproducible, high-density High-throughput Screening (HTS) readouts to simplify day-to-day 3D cell culture. With this step, faCellitate reinforces…
3-dimensional cell cultures are fast becoming the new standard for in vitro cell culture research owing to their efficient ability to mimic in vivo biology. To encourage this movement from 2D into 3D culture, proper…
Space exploration has always captured the human imagination, and as we venture beyond our planet, the study of human physiology in microgravity environments has become increasingly vital. 3D organoids, miniature organ models grown from human…
A spheroid is a three-dimensional (3D) cell culture model that mimics the in vivo environment more closely than traditional two-dimensional (2D) monolayer cultures. Physiologically, spheroids exhibit several distinct characteristics compared to 2D cell cultures. This…
Since its introduction, 3D cell culture has revolutionized cancer research by providing an efficient and modifiable research platform, that recapitulates in vivo like cell structure, function, gene expression and tissue microenvironment, all of which are…
Cancer is one of the most threatening diseases and leading cause of death worldwide (1). Intra- and intertumoral heterogeneity is often responsible for metastasis formation, treatment failure, and therapy resistance. The increase in the cost…
The rather low success rates in new drug development and the increased costs suggest that alternative and robust strategies are required to improve early drug discovery. Two-dimensional (2D) monolayer cultures do not provide a true…
Multicellular spheroids (MCSs) are formed through spontaneous aggregation of cells in the presence of adhesion molecules known as cadherins (1). Decades of research have proved MCSs to be an efficient 3D cell culture model for…
Human primary cells are isolated directly from human tissues and maintain the physiological characteristics of their original tissue. This article discusses the most common primary cells used by scientists (1,2). Endothelial cells In the human…
Normally, human cells grow and divide to form new cells and as the cells grow old or are damaged, they are replace with new cells. When this order of cell cycle breaks down and cells…