Spheroids are three-dimensional (3D) cell aggregates that can mimic tissues and mimic tumors. In recent years, there has been significant progress in development of in vitro aggregates. Epidermal spheroids provide a more representative view of the human skin than 2D…
Three-dimensional culture system provides unique platforms to study complex biological processes in vitro, particularly cell proliferation, differentiation, motility, and stress responses. While 3D spheroid cultivation methods are well established in certain tissue types such as mammary and colorectal epithelial cells,…
Bian et al. recently developed protocols for genetically manipulating cerebral organoids to induce glioblastoma tumor growth named neoplastic cerebral organoids. This method uses CRISPR-based genome editing tools to create either oncogenic mutation or induce the expression of oncogenes to cause…
In the recent years 3D cultures of tumour cell lines have become an essential tool in cancer research and drug discovery processes. 3D cultures when compared with traditional 2D monolayer cultures, are able to produce cell cultures bearing close resemblance…
Remarkable advancements have been made in the ability to print complex tissue, including 3D model of Glioblastomas and other cancers. In 2019 Yi et al. published a new approach for creating a 3D bio-printed glioblastoma-on-a-chip model from patient derived cells…
Modern drug discovery processes has encountered significant setbacks in the past decades despite the technological advances made in analytical tools and research model development. This is primarily because of the use of inadequate biological models that do not mimic in-…
To address the modelling of cell-to-cell communication with the cell population and the development of vasculature in organoid system, significant progress has been achieved with blood vessels organoids which shows a great potential to impact research into vascular diseases. Despite…
Drug development is often a lengthy and costly process. Despite the technological advancements made in this regard in the past century, it still has low success rates in clinical trials. Presently over half of drugs that make to Phase 2…
The many failures encountered in drug discovery processes have propelled the advancement of reliable research platforms to better mimic in-vivo like cellular structure and function thereby obtaining physiologically relevant cellular responses to drugs. To this end researchers have focused on…
Modern drug discovery processes has encountered significant setbacks in the past decades despite the technological advances made in analytical tools and research model development. This is primarily because of the use of inadequate biological models that do not mimic in-…